Moselio Schaechter


  • The purpose of this blog is to share my appreciation for the width and depth of the microbial activities on this planet. I will emphasize the unusual and the unexpected phenomena for which I have a special fascination... (more)

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« Measuring the Strength and Speed of the Microbial Grappling Hook | Main | A Close Encounter of the Enological Kind »

January 28, 2010

Fine Reading: Yet Another Reason to Appreciate Fungi

by Elio

This blog, known as it for taking up the cause of the underdog, was fortified by reading How Fungi Have Shaped Our Understanding of Mammalian Immunology in a recent issue of Cell Host and Microbe. Not only that, but this is an exceptional piece of reviewing. It’s short (a mere three pages), fun to read, and to the point.

So, what’s the case for fungi shaping our understanding of immunology? (Note the inclusion of “mammalian” in the title. A nice departure from the customary anthropocentricity). The author, Gordon Brown of Aberdeen, guides us through both early and late developments, starting with Elie Metchnikoff, the discoverer of phagocytosis who saw yeast cells being engulfed by the water flea Daphnia, through C-type lectins, Toll and Toll-like receptors, and intracellular signal pathways.

Timeline_2

Selected seminal discoveries from 1884 to 2006 are shown along with representative images,
including Metchnikoff (1884); zymosan engulfment by PMN (1941); properdin (1954, trimeric
structure); Aspergillus infection in TLR-deficient Drosophila (1996); fungal recognition by
Dectin-1-expressing fibroblasts (2001); collaborative signaling between TLR and CLRs (2003);
ITAM-like motifs and Syk kinase recruitment (2005); the requirement of multiple PRRs for
optimal anti-Candida responses (2006); and enhanced Candida infection in the kidneys of
CARD9−/− mice (2006). Source.

In the author’s words: …fungi and their components have long been known to influence immune function, and the contributions made from the study of fungal infections are often underappreciated. Well, here’s for trying.

Comments

Thanks for flagging that up Elio - from my view on the other side of this huge mountain known as immune function, I agree that "contributions made from the study of fungal infections are often underappreciated". The way some others (medical and lay people) constantly jump to talking about white blood cells attacking, or of immune responses triggered by single pathogens, constantly frustrates me in its simplicity of thinking. Wish I could see the whole article.

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