Moselio Schaechter


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« Putting Redundancy to Work | Main | Holey Biofilm! »

April 04, 2013

Microbes or Not, Parasites All

by Elio

Figure1
The adult protozoon, Spirochona gemmipara, on the gills of a crustacean. Source.

Parasites pose a problem for the semantically-oriented microbiologist. There is no question that unicellular parasites such as Giardia, Plasmodium, or Toxoplasma are microbes, thus we can appropriate them with impunity. But what about parasitic worms? They are clearly not microscopic* and are taxonomically apart from parasitic protist. Yet parasitic protists and metazoans are taught alongside one another in the microbiology classroom and they are often considered in unison by epidemiologists and others. For all their phylogenetic divide and apparent differences, they all share the general traits of a parasitic life style, including undergoing the same steps in pathogenesis (encounter with the host, entry, survival, multiplication, causing damage) and eliciting complex immune responses.

Figure2
A nematode, Strelkovimermis spiculatus, parasitizing a mosquito larva. Source.

Particularly fascinating is that parasites have evolved intricate mechanisms to survive inside the host and ensure their transmission. Many parasites, whether unicellular or multicellular, go through life cycles that are ultra-baroque in complexity. Consider, for example, the malaria plasmodia’s contortions both within the mosquitoes and the humans. Plasmodia interact with at least three kinds of cells in the insect host and go through some six different stages of differentiation in the human host (including sex). Or ponder about certain flukes that go through as many as four distinct hosts in their life cycle! 

So, somewhere along the line, us microbiologists should consider nuzzling up to the metazoan parasites, at least to learn more about them. The Internet is a good place to start, with a number of fine blogs, articles, and other forms of social media that are both informative and exciting. Visiting them is more than just worthwhile. Here is a partial list:

This Week in Parasitism is an ASM-sponsored podcast hosted by Vincent Racaniello and Dickson Despommier where a wide range of issues of parasitism are artfully discussed.

Parasite of the Day presents a parade of unusual and unexpected parasites, from some that are found in tar pits to others that feed on mosquito larvae.

Pretty Protozoa deals with unicellular parasite species in ways that satisfy both the eye and the mind.

10 Astonishing Examples of Bizarre Parasitic Life Cycles presents a small parade of parasites, from those that make their crab host dance, to one that eat the fish host’s tongue, to those that make their fly host dive in a lake.

The Artful Amoeba has exquisitely written articles, occasionally on parasitic forms.

*A human tapeworm can reach 10 meters in length, that of a whale, 40 meters.

Comments

The link for The Artful Amoeba takes us to JF's old page -- no less enthralling in its static majesty -- while her new postings appear at http://blogs.scientificamerican.com/artful-amoeba/ . Steal time, if you can, to keep up with her Olympian publishing schedule.

"Parasite Gal," a pathologist at Mayo Clinic, puts up a quiz each week in which she invites the readers to guess the parasite (usually based on pictures from her microscope). Her clinical identification is given at the end of the week:
http://parasitewonders.blogspot.com/

Protists and bacteria make frequent appearances but Diphyllobothrium was featured a few weeks ago:
http://parasitewonders.blogspot.com/2013/02/case-of-week-246.html

--bks

"Plasmodia interact with at least three kinds of cells in the insect host and go through some six different stages of differentiation in the human host (including sex)."

I think you may have that info reversed. Sexual differentiation begins in the human stage as gametocytes form from the otherwise asexual schizogonus replicating parasites, but sex is completed within the mosquito (once the flagella come out ;).

Elio replies:

You are right but I was not totally off, being that the sexual cycle starts with gametogenesis in the human and is complete by conjugation of gametes in the mosquito. Can we split the difference? Sex can be complicated, no?

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