Speak or Swim – But Not Both

by Elio
 

The Electron micrograph (here) and the diag­ram (be­low)  are courtesy of Noreen Francis, Dennis Thomas and David DeRo­sier.

Many pathogenic bacteria "speak" a chemical language by inserting proteins into host cells that affect the mi­crobe's ability to invade or damage the host.  For the insertion, they use a complex needle made up of a number of proteins (called a Type III secretion system). Similar proteins in similar structural arrangements are also involved in making the basal body of the flagella used for swimming. The two pieces of machinery, though differing in function, are evolutionarily related. Not only that, they interact with one another.
 

A recent study by a lab in Marseilles  reveals that Pseudo­monas aeruginosa can make only one of these pieces of machinery at a time, not both. No flagella, more Type III machinery, and conversely more Type III machinery, fewer flagella.  The authors sagely propose that some virulence factors are coordinated but inversely regulated.  Which are turned on and which are turned off likely depends on the differing demands of different stages and types of infection.
 
 
 

The structure of the bacterial basal  body of flagella has been recently reported in its full splendor from David DeRosier's lab.
 

 

 

 

 

 

 

Comments

[Robert Murray]

This observation points out and reinforces a principle that cells do not get rid of a mechanism (set of genes)when they are no longer required but conserves them for another possible use or for modification so that a new process or structure can be utilized. The transport systems' relationship to flagella motors is a great example. There are probably more variations on the remarkable structure of ATPase than we know now, and this is the more interesting because like the step of making a flagella motor there is a moving element in that complex of molecules. Presumably there are many examples and so there should be a sort of phylogeny for the development oof functional components. Maybbe this could be like the elaboration of super-antigens of Streptococci over the past fifty year. What will they be used for next? It resemblles the gadgeteers box of collected scraps of "junk"that may be useful sometime.