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Paul Orwin

Since I'm killing time before giving an exam, I spent some time sleuthing (don't have access to the paper, since I let my Science sub slide). The fragment in glucose-6-phosphate dehydrogenase is not NNWNN, but rather NNWDN (aspartate for asparagine), at least in the two E. coli protein refs I looked at on NCBI. So, there must be a post translational or post cleavage modification to convert that aspartate to asparagine. I'm not a good enough biochemist to know how this works, although a quick google reveals an asparagine synthetase that could do the job, if it can work on aspartate in the middle of a peptide (which seems weird, actually). It sounds like there is a lot of interesting stuff to figure out here!!

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