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Paul Orwin

As someone who used to dabble in that area (in the halcyon days of graduate school), I'm glad to see that interest persists, and spreads from the clinical aspects to the more fundamental. I like your neologism as well. The massive superantigen amplification (SAg for short) that seems to have occurred in S. aureus is an interesting phenomenon, and the SaPIs seem a reasonable mechanism for the formation of all of these proteins by recombination, phage replication, and integration events. I wish I had more insight into the mechanics (I haven't read all the Novick group papers - they've been very active!) of the process. Is it sensible to consider SaPIs to be parasites of bacteriophages? If I have more constructive thoughts i'll add them...

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