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Interesting thoughts! I'd say irreparable. The rupture is huge, sometimes more than a micron. Its formation causes immediate loss of membrane potential, thus cessation of ATP production. Prior to hole formation, a large amount of endolysin accumulates in the cytoplasm, so cell lysis comes almost instantly once the membrane has been ruptured---within seconds.

For a bit more of the story, check out my previous post: Time's Up.


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