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As usual, you ask questions for which there are no answers, at least not yet.

I'd say that there are many reasons why they might not work in eukaryotic cells, but that does not mean that any of those possible reasons actually prevent it. I would not have expected them to function in both bacterial and archaeal cells.

As to being limited to extreme environments, might be. But they aren't even found in other, closely-related extremophilic Archaea. Just a few. Their ability to outcompete other lysis mechanisms might also have something to do with virion morphology. Another possibility is that although the pyramids can form in a bacterial membrane, we don't know yet if the mechanism that controls their opening or the time of lysis can work in a bacterium.

Yep. More questions.


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