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Mark O. Martin

I am just starting to chat with my class about how immunology and microbiology interact. Much of the focus is on adaptive immunity, from the student point of view. And that is fine.

But I LOVE the clear evidence of ancient coevolution that is implicit in tales such as this one! And not just about pathogenicity, but about symbioses as well (the TCT story in both Vibrio fischeri and Bordetella pertussis: one interaction is developmental and symbiotic, and the other is pathogenic; same molecule!). Ditto the wonderful transition of the term PAMP into MAMP.

The dead hand of Darwin is on every living thing, and this is a wonderful example...and not to be easily found in textbooks!

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