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Dr Keith Firman

This reminds me of some work we did many years ago, not about protein folding, but to do with protein-protein interactions (equally critical to function in E. coli). What we found is that even a slightest change to the dissociation constant for such an interaction (e.g. a small charge change) would lead to loss of enzyme function.
Lisle, W et al (2000. Molecular Biology Today 1: 57-64.
This is just another example of how balanced teh living cell is.

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