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Andrew Ryan

In sporulation the excision only occurs in the mother cell which is terminally differentiated--excision does not occur in the prespore chromosome, so that upon germination and growth the population will maintain the phage.

Therefore, in Listeria, if the phage excises during infection, how is it maintained in the Listeria population at all? Shouldn't clinical isolates lack this phage? Isn't the presence of the phage evidence that this phenomenon does not occur during human infection? Or am I missing something?

Marvin replies: I assume that excision does not occur in 100% of cells and thus a small subpopulation maintains the phage.

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