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Christoph Weigel

A good question Daniel, yet certainly easier to answer (by experiments) in E. coli or yeast! I passed your question to Axel Visel, here his reply: "based on everything that we know about the way enhancers work (binding of specific transcription factors to their respective binding sites, which consist of short DNA motifs), my expectation is that if an enhancer gets replaced with random sequence (that does not contain any particular DNA motifs), we should see a phenotype very similar or identical to the enhancer deletion". I wonder whether something like a pure 'random sequence' really exists - probably one would have to test several 'random sequences' to make sure that the effect is in all cases the same. But this is almost a talmudic question...

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