Small Things Considered

Evolution-Proofing Antibiotics

by Vilhelmiina Haavisto | Since the dis­co­ve­ry of pe­ni­cil­lin and its de­vel­op­ment in­to a the­ra­peu­tic agent, an­ti­bio­tics have re­vo­lu­tion­ized me­di­cine and saved count­less lives. How­ever, the way we use these life-sav­ing me­di­cat­ions is fun­da­men­tal­ly un­sus­tain­able as pa­tho­gens ra­pid­ly evolve re­sist­ance, ren­der­ing ma­ny se­ri­ous in­fect­ions ef­fect­ive­ly un­treat­able. Read more →

Why Calcify?

by Roberto | Janie's re­cent Bio-Brick post, where she in­tro­duces mi­cro­bi­al­ly in­duced cal­cite pre­ci­pi­ta­tion, prompt­ed me to con­tinue on the to­pic. In con­trast to the amor­phous chalk Janie de­scribed, which is pro­duced by bac­te­ria from lime­stone, I'll be de­scrib­ing a ve­ry dif­ferent sort of chalk. Still cal­cium car­bo­nate, but with a com­ple­te­ly dif­fer­ent ge­ne­sis. Read more →

Transient Thoughts on Transduction

by Roberto | What with the all the talk about CRISPR, the renewed interest in phage therapy, the widespread occurrence of huge phages (to mention but a few of the reasons phage are constantly in the news these days), it's no exaggeration to say that once again in biology "phage are all the rage"... Read more →

Fine Reading: Evolution of Pathogen Tolerance

by Roberto | While reading a review yesterday, I recalled a conversation I had with a student nearly forty years ago. He did not appear interested in the subject of my lectures – bacterial genetics and physiology – so I was curious to know the reasons why. Read more →

Prokaryotic Organelles. Yes, There Are Such Things.

by Elio | One of the venerable distinctions between eukaryotes and prokaryotes used to be that prokaryotes do not have organelles. This distinction has now gone by the wayside because bacteria and archaea have been shown to possess protein bound structures that can appropriately be called organelles. Read more →

All the World Is Not E. coli

by Elio | Like most people interested in bacterial physiology, I spent much of my life with the nearly religious persuasion that the starting condition for studying growth is when cells and their constituents all increase in unison. In practice, such "balanced growth" is achieved when bacteria grow exponentially at low concentrations... Read more →

Of Terms in Biology: Sympatry and Allopatry

by Elio | Sympatry means that two species coexist in the same physical area, allopatry that they don't. The etymology of the suffix patris, helps. It comes from the Latin for 'fatherland,' as in 'patriot' (or, for those who remember the Marseillaise, "Alons enfants de la Patrie"). Read more →

Putting Life on Earth in Perspective

by Roberto | Last week I was very fortunate. I had the opportunity to focus my attention on putting life on Earth in perspective. It was a welcome respite considering these trying times. Almost one year ago, thanks to Nassos Typas, I received an invitation to speak on microbial diversity at the European Molecular Biology Laboratory (EMBL) in Heidelberg... Read more →

Unicellular Capsaspora and animal multicellularity

by Victoria Shabardina | It is common in biolo­gy to look at little things to learn how the big parts work: we study mo­le­cul­es to un­der­stand cells and study or­gans to know how the bo­dy funct­ions. But it is dif­fer­ent with Cap­sa­spo­ra, be­cause it is a whole, a com­plete single-cell or­gan­ism, and it is ac­ti­ve­ly stu­died for elu­ci­dat­ing how... Read more →

Bacterial Genomes, IKEA-Style (Some Assembly Required)

by Janie | Much like “artificial” languages like Esperanto or Tolkien's fifteen (!) Elvish tongues, genomes, too, are subject to manipulation and modulation, by the scientist's hand. There's been a smattering of posts here on the blog that touched on synthetic genomes... Read more →