Two recent events prompt me to post this (double) Talmudic Question(s). First, I had a lot of thoughts inspired by Christoph's Monday post on stop codons being recognized by charged tRNAs in a trypanosomatid: "Stops making sense." How bizarre can non-canonical codes get? Second, I was reading posts from the past.
There are plenty of natural product families that inhibit essential enzymatic functions in cell wall synthesis (e.g., ß-lactams, glycopeptides), translation (e.g., aminoglycosides, tetracyclines) and transcription (e.g. rifampicin). Yet, there are very few (if any) natural products that specifically inhibit bacterial DNA polymerase. Why have such compounds not been found?